This overstimulation is the primary way that nerve agents kill. However, by blocking the action of acetylcholine at muscarinic receptors, atropine also serves as a treatment for poisoning by organophosphate insecticides and nerve agents, such as tabun (GA), sarin (GB), soman (GD), and VX.Ītropine works by blocking acetylcholine receptors, preventing their overstimulation. How is atropine an antidote?Ītropine is not an actual antidote for organophosphate poisoning. Therefore, the best thing to do is avoid exposure: Leave the area where the VX was released and get to fresh air. Recovery from VX exposure is possible with treatment, but the antidotes available must be used quickly to be effective. It is used to treat organophosphate poisoning in conjunction with atropine and either diazepam or midazolam. Pralidoxime (2-pyridine aldoxime methyl chloride) or 2-PAM, usually as the chloride or iodide salts, belongs to a family of compounds called oximes that bind to organophosphate-inactivated acetylcholinesterase. Atropine should be administered every 5 to 10 minutes until secretions begin to dry up.įlumazenil (Romazicon®) is the antidote for benzodiazepines, such as diazepam (Valium®), lorazepam (Ativan®), and midazolam (Versed®), and must be administered intravenously. There is also generally no benefit in giving more than three injections of 2-PAM Cl. Which drug is an antidote for nerve gas?Īntidotes for nerve agent toxicity are atropine and pralidoxime. How does atropine work as an antidote to nerve agents?ĪNTIDOTE: Atropine and pralidoxime chloride (2-PAM Cl) are antidotes for nerve agent toxicity however, 2-PAM Cl must be administered within minutes to a few hours (depending on the agent) following exposure to be effective.How does convulsant Antidote Nerve Agent ( CANA ) work?.

Which drug is an antidote for nerve gas?.

Midazolam antidote